The bus station (Terminal de Omnibus) is approximately five kilometers southeast of the city center, thus it is best to take a cab or bus into town (buses number 8, 38, and many more). The Avenida Fernando de la Mora, which runs in front of the bus station, connects to the city center. All bus companies have ticket offices within the station, while several long-distance bus companies have offices in the microcentro surrounding Plaza Uruguaya.
There are two kinds of bus services to the country’s major cities: comn and directo. While the first is less expensive, it also stops in every town or bus stop along the route to pick up and drop off passengers, taking longer than the directo, which runs directly or with fewer or no stops to reach their destination in less time. Directo buses are less regular, with just a few runs each day, usually around midnight, early in the morning, or late in the afternoon.
- Encarnación, común: 7–8 hours, several daily, 50,000 Gs; also directo: 5 hours, 75.000 Gs
- Ciudad del Este, several daily, 5–7 hours, 40,000 – 70,000gs
- Concepción, about 6 hours, several daily, 60’000 Gs
- Cities in the Chaco: Loma Plata, Filadelfia, Neuland, Mariscal Estigarriba, about 8 hours, 1 to 2 services daily to each destination, 90,000 Gs (NASA, Golondrina).
International buses leave from the bus station towards Argentina, Brazil, Uruguay, Bolivia, and Chile.
- Buenos Aires, ca. 17h, several daily, 45 US$ (Crucero del Norte, Nuestra Señora de la Asunción/Chevallier)
- Santa Cruz, $40, 21 hours.
The bus to Santa Cruz de la Sierra, Bolivia, is not recommended because it is extremely slow (the Transchaco Highway is only paved as far as the Bolivian border), buses generally travel only at night, missing out on any views of the Chaco, and roadblocks on the Bolivian side of the border are common, easily doubling your journey time. The majority of buses traveling this route (at least 21 hours) do not have bathrooms on board. Flights to Santa Cruz are currently just slightly more costly than taking the bus if purchased in advance.
All of the other buses are excellent. It is prudent to pay more money to get better service (the 70,000 Gs. bus to Ciudad del Este takes two to three hours less than the 40,000 Gs. services, for example). Food and drink are often supplied on longer-distance trains, and virtually all will stop on way to let someone sell chipa and cocido.